Department of Neurology, Medical University of Vienna, Vienna, Austria.
Headache. 2012 Sep;52(8):1236-45. doi: 10.1111/j.1526-4610.2012.02166.x. Epub 2012 Jun 1.
The aim of this study was to examine factors increasing and decreasing the risk of occurrence of migraine aura and of headache and migraine not associated with aura (HoA, MoA) prospectively by means of a daily diary.
Of 327 patients with migraine completing a comprehensive diary up to 90 days, we selected all patients who recorded at least 1 episode of migraine aura. To find risk indicators and triggers of aura, HoA, and MoA, we analyzed 56 variables and calculated univariate and multivariate generalized linear mixed models.
Fifty-four patients recorded a total of 4562 patient days including 354 days with migraine aura. In the multivariate analysis, the risk of aura was statistically significantly increased by smoking, menstruation, and hunger, and it was decreased by holidays and days off. The risk of HoA and/or MoA was increased during menstruation, by psychic tension, tiredness, and odors, and it was decreased by smoking.
Menstruation is the most prominent factor increasing the risk of aura as well as that of HoA and MoA. Smoking shows the most striking difference increasing the risk of aura, but decreasing the risk of HoA and MoA.
本研究旨在通过每日日记前瞻性地检查增加和减少偏头痛先兆和与先兆无关的头痛和偏头痛（HoA，MoA）发生风险的因素。
在完成了长达 90 天的全面日记的 327 名偏头痛患者中，我们选择了记录至少 1 次偏头痛先兆的所有患者。为了寻找先兆、HoA 和 MoA 的风险指标和诱因，我们分析了 56 个变量，并计算了单变量和多变量广义线性混合模型。
54 名患者共记录了 4562 个患者日，其中包括 354 个偏头痛先兆日。在多变量分析中，先兆的风险与吸烟、月经、饥饿呈统计学显著增加，而与假期和休息日呈统计学显著降低。月经期 HoA 和/或 MoA 的风险增加，而精神紧张、疲劳和气味则增加了先兆的风险，吸烟则降低了先兆的风险。
月经是增加先兆以及 HoA 和 MoA 风险的最显著因素。吸烟对先兆风险的影响最大，但对 HoA 和 MoA 风险的影响最小。
