Spies G, Fennema-Notestine C, Archibald S L, Cherner M, Seedat S
South African Research Chairs Initiative (SARChI), PTSD Program, Department of Psychiatry, University of Stellenbosch, Cape Town, South Africa.
AIDS Care. 2012;24(9):1126-35. doi: 10.1080/09540121.2012.687813. Epub 2012 Jun 6.
The study investigated the behavioral and brain effects of childhood trauma and human immunodeficiency virus (HIV) infection, both separately and in combination, and assessed potential interactions in women who were dually affected. Eighty-three HIV-positive and 47 matched HIV-negative South African women underwent neuromedical, neuropsychiatric, and neurocognitive assessments. Univariate tests of significance assessed if either HIV infection or childhood trauma, or the combination, had a significant effect on neurocognitive performance. The majority of women were Black (96%) and had an average age of 30 years. An analysis of covariance revealed significant HIV effects for the Hopkins Verbal Learning Test (HVLT) learning and delay trials (p < 0.01) and the Halstead Category Test (HCT) (p < 0.05). A significant trauma effect was seen on the HVLT delay trial (p < 0.05). The results provide evidence for neurocognitive dysfunction in memory and executive functions in HIV-infected women and memory disturbances in trauma exposed women.
该研究分别及综合调查了童年创伤和人类免疫缺陷病毒（HIV）感染对行为及大脑的影响，并评估了双重受影响女性中的潜在相互作用。83名HIV阳性和47名匹配的HIV阴性南非女性接受了神经医学、神经精神病学和神经认知评估。单因素显著性检验评估了HIV感染、童年创伤或两者结合是否对神经认知表现有显著影响。大多数女性为黑人（96%），平均年龄为30岁。协方差分析显示，霍普金斯言语学习测验（HVLT）学习和延迟试验（p<0.01）以及霍尔斯特德类别测验（HCT）（p<0.05）存在显著的HIV效应。在HVLT延迟试验中观察到显著的创伤效应（p<0.05）。结果为HIV感染女性的记忆和执行功能神经认知功能障碍以及受过创伤女性的记忆障碍提供了证据。
