Gun Eryilmaz Ozlem, Tavil Betul, Turan Serpil, Yumusak Omer, Doganay Melike, Uzunlar Ozlem, Akar Serra, Eyi Elif Gul
Department of Perinatology, Zekai Tahir Burak Women's Education and Research Hospital Department of Hematology, Ankara Children's Hospital Department of Biochemistry, Ankara Numune Hospital, Ankara, Turkey.
J Obstet Gynaecol Res. 2013 Jan;39(1):175-9. doi: 10.1111/j.1447-0756.2012.01896.x. Epub 2012 Jun 4.
To compare hepcidin and erythropoietin levels in the cord blood of neonates with meconium-stained amniotic fluid (MSAF) to levels obtained from age-, body mass index- and gravidity-matched neonates with clear amniotic fluid.
A cross-sectional controlled study was conducted in secondary and tertiary care centers. Cord blood samples of 40 neonates following term gestations (≥37 weeks' gestation) with MSAF and 40 maternal age-, body mass index- and gravidity-matched controls with clear amniotic fluid were analyzed in this study. Demographic data, delivery outcomes and laboratory evaluations were recorded.
Cord blood pH levels were lower in fetuses with MSAF when compared to those with clear amniotic fluid (P=0.0001). Fetuses with MSAF had higher cord blood erythropoietin levels in comparison to those with clear amniotic fluid (P=0.0001). Delivery outcomes and hepcidin measurements were similar in both groups.
We demonstrated a significant relationship between erythropoietin levels and meconium passage, but failed to show the existence of a relationship between hepcidin levels and meconium passage.
比较羊水胎粪污染（MSAF）新生儿脐血中铁调素和促红细胞生成素水平与羊水清、年龄、体重指数和妊娠次数匹配的新生儿的相应水平。
在二级和三级护理中心进行一项横断面对照研究。本研究分析了40例足月妊娠（≥37周）且羊水胎粪污染的新生儿的脐血样本以及40例年龄、体重指数和妊娠次数与产妇匹配且羊水清的对照新生儿的脐血样本。记录人口统计学数据、分娩结局和实验室评估结果。
与羊水清的胎儿相比，羊水胎粪污染的胎儿脐血pH值较低（P = 0.0001）。与羊水清的胎儿相比，羊水胎粪污染的胎儿脐血促红细胞生成素水平较高（P = 0.0001）。两组的分娩结局和铁调素测量结果相似。
我们证明了促红细胞生成素水平与胎粪排出之间存在显著关系，但未能表明铁调素水平与胎粪排出之间存在关系。
