Department of Dermatology, Al-Minya University, Al-Minya, Egypt.
J Cosmet Dermatol. 2012 Jun;11(2):122-30. doi: 10.1111/j.1473-2165.2012.00606.x.
As the demand for minimally invasive rejuvenation is increasing, micropeel resurfacing using Erbium:Yttrium Aluminum Garnet (Er:YAG) laser 2940 nm has been reported for the treatment of photoaged skin without ablation of the epidermis. However, little is known about the efficacy and underlying histologic changes associated with this type of treatment.
The aims of this study are to evaluate the clinical effect and objectively quantify the histological changes in response to multiple sessions of Er:YAG laser 2940 nm mini-peels.
Six female volunteers of Fitzpatrick skin type III-IV and Glogau's class I-III wrinkles were subjected to six microresurfacing peels at 2-week intervals using Er:YAG 2940 nm laser at subablative fluences of 2-3 J/cm(2) to treat periorbital rhytides. Quantitative evaluation of collagen types I, III, and VII, newly synthesized collagen, total elastin, and tropoelastin was performed by histochemistry and immunohistochemistry coupled with computerized morphometric analysis at base line, end of treatment, and 3 months post-treatment.
Compared to the base line, evaluation of volunteers revealed obvious clinical improvement in response to Er:YAG mini-peels. Collagen types I, III, and VII, as well as newly synthesized collagen, together with tropoelastin showed a statistically significant increase in response to treatment, while the mean level of total elastin was significantly decreased in response to treatment. However, this was followed by regression of improvement at 3 months post-treatment but was still better than baseline.
This study revealed that multiple Er:YAG mini-peels is a promising treatment option for photoaging as it reverses the signs of photoaged skin with little downtime and side effects. However, to maintain the short-term improvement achieved after treatment, continued Er:YAG 2940 nm laser mini-peels is required.
随着微创焕肤需求的增加，使用铒雅铬石榴石（Er:YAG）激光 2940nm 的微剥脱术已被报道用于治疗非表皮消融的光老化皮肤。然而，对于这种治疗类型的疗效和潜在的组织学变化知之甚少。
本研究旨在评估 Er:YAG 激光 2940nm 微剥脱术多次治疗的临床效果，并客观量化组织学变化。
6 名女性志愿者，皮肤类型为 Fitzpatrick III-IV 型，Glogau 皱纹分级为 I-III 级，接受 Er:YAG 2940nm 激光 6 次微剥脱治疗，间隔 2 周，亚消融能量为 2-3J/cm²，治疗眶周皱纹。在基线、治疗结束时和治疗后 3 个月，通过组织化学和免疫组织化学结合计算机形态计量分析，对 I、III 和 VII 型胶原、新合成的胶原、总弹性蛋白和原弹性蛋白进行定量评估。
与基线相比，志愿者的评估显示 Er:YAG 微剥脱术的治疗反应明显改善。I、III 和 VII 型胶原以及新合成的胶原和原弹性蛋白的水平均有统计学意义的增加，而总弹性蛋白的平均水平则在治疗后明显下降。然而，这一改善在治疗后 3 个月时出现了消退，但仍优于基线。
本研究表明，多次 Er:YAG 微剥脱术是治疗光老化的一种有前途的选择，因为它可以逆转光老化皮肤的迹象，且恢复时间短，副作用小。然而，为了维持治疗后获得的短期改善，需要继续进行 Er:YAG 2940nm 激光微剥脱术。
