Shanghai Institute of Pharmaceutical Industry, National Pharmaceutical Engineering & Research Center, China State Institute of Pharmaceutical Industry, Shanghai, China.
CNS Neurosci Ther. 2012 Jun;18(6):471-4. doi: 10.1111/j.1755-5949.2012.00323.x.
Stroke is a major cause of disability and death worldwide. Hypertension is one of the most important risk factors for stroke. The objective of this work was to study the synergic effects of levamlodipine and bisoprolol on blood pressure reduction and organ protection in spontaneously hypertensive rats (SHR).
Blood pressure was continuously monitored in conscious SHR. For acute study, a single dose of drugs was administrated via an intragastric catheter. For chronic study (4 months), drugs were delivered via rat chow.
A single dose of levamlodipine (from 1 mg/kg), bisoprolol (from 0.125 mg/kg), and their combinations significantly decreased blood pressure. The levamlodipine-induced tachycardia and the bisoprolol-induced bradycardia were temporized by the combination of these two drugs. Upon chronic treatment, this combination also decreased blood pressure variability and reduced organ damage.
Levamlodipine and bisoprolol produce synergic effects on blood pressure reduction and organ protection in SHR.
卒中是全世界范围内导致残疾和死亡的主要原因。高血压是卒中最重要的危险因素之一。本研究旨在探讨左旋氨氯地平和比索洛尔联合应用对自发性高血压大鼠（SHR）降压和器官保护的协同作用。
通过胃管给予单次剂量的药物，连续监测清醒 SHR 的血压。在慢性研究（4 个月）中，通过大鼠饲料给予药物。
单次给予左旋氨氯地平（1mg/kg）、比索洛尔（0.125mg/kg）及其联合用药均可显著降低血压。这两种药物联合应用可缓解左旋氨氯地平引起的心动过速和比索洛尔引起的心动过缓。在慢性治疗中，该联合用药还可降低血压变异性并减少器官损伤。
左旋氨氯地平和比索洛尔联合应用对 SHR 的降压和器官保护具有协同作用。
