Department of Colorectal Surgery, University Hospital Coventry, Coventry, UK.
Colorectal Dis. 2013 Jan;15(1):74-9. doi: 10.1111/j.1463-1318.2012.03120.x.
The national Bowel Cancer Screening Programme has been rolled out nationwide following pilot screening in two health authorities in the UK. The aim of this study was to define overall 5-year survival of screen detected cancers and to compare the overall survival outcome of screened vs symptomatic patients over a 10-year period.
All patients with colorectal cancer treated at one trust in patients of screening age (50-69 years) during the pilot screening programme (2000-2008) were analysed. Patients were defined as screen detected or symptomatically detected. Disease pathology and recurrence data were obtained from the hospital's computerized results reporting system and mortality was cross-matched with data from the West Midlands Cancer Intelligence Network.
In all, 633 patients aged 50-69 were identified in the study period; 155 patients had a screen detected cancer and 478 did not. A log-rank test completed on survival outcomes indicated that survival was significantly worse in the symptomatic group. This difference persisted if only patients treated with curative intent were considered.
Survival outcome was significantly better in the screened vs the symptomatic population in all groups and also in those treated for curative intent. There was a trend towards better survival for screen detected cancer when compared stage for stage.
英国在两个卫生部门进行试点筛查后，全国范围内推出了国家结直肠癌筛查计划。本研究的目的是定义筛查发现癌症的总体 5 年生存率，并比较 10 年内筛查患者与症状患者的总体生存结果。
分析了在试点筛查计划（2000-2008 年）期间，一个信托机构中所有处于筛查年龄（50-69 岁）的结直肠癌患者。患者被定义为筛查发现或症状发现。疾病病理和复发数据来自医院的计算机化结果报告系统，死亡率与西米德兰兹癌症情报网络的数据交叉匹配。
在研究期间，共确定了 633 名 50-69 岁的患者；155 名患者患有筛查发现的癌症，478 名患者没有。生存结果的对数秩检验表明，症状组的生存率明显较差。如果只考虑有治愈意图治疗的患者，这种差异仍然存在。
在所有组中，筛查组与症状组的生存结果明显优于症状组，在有治愈意图治疗的患者中也是如此。与分期相比，筛查发现的癌症有更好的生存趋势。
