Department of Chemistry, Punjab University, Chandigarh 160014, India.
Bioorg Med Chem Lett. 2012 Jul 1;22(13):4225-8. doi: 10.1016/j.bmcl.2012.05.047. Epub 2012 May 19.
An efficient asymmetric Michael addition of cyclic ketones to β-nitrostyrenes using secondary diamine as an organocatalyst derived from l-proline and (R)-α-methylbenzyl amine has been described. This pyrrolidine based catalyst 1 was found to be very effective to synthesize various γ-nitrocarbonyl compounds in good yield (up to 81%) with excellent stereoselectivity (up to >99:1 dr and >99% ee).
已描述了一种使用脯氨酸和（R）-α-甲基苄胺衍生的仲二胺作为有机催化剂，实现环状酮对β-硝基苯乙烯的高效不对称迈克尔加成反应。该基于吡咯烷的催化剂 1 被发现非常有效地合成各种γ-硝基羰基化合物，产率高（高达 81%），立体选择性好（高达 >99:1 dr 和 >99%ee）。
