Sato Masafumi, Kariya Kazuhiro, Matsumoto Munetaka, Itoh Miyuki, Kobayashi Yoshiyasu, Nishifuji Koji, Kamiie Junichi, Shirota Kinji
AC Plaza Kariya Animal Hospital, 5-20-2 Morishita, Koto-ku, Tokyo, Japan.
J Vet Med Sci. 2012 Oct;74(10):1337-9. doi: 10.1292/jvms.12-0117. Epub 2012 May 25.
Multiple, pigmented, verrucous, cutaneous lesions in a 2-year-old female cat were pathologically examined. The lesions were linearly arranged on the right side of the body, and had developed along with moderate pruritus since infancy. Histologically, prominent exophytic, papillomatous outgrowths of the epidermis and acanthosis with intense ortho and parakeratotic hyperkeratosis were characteristic of the lesions. Dermal inflammation with mononuclear cells, neutrophils, and eosinophils was also noted. Inclusion bodies, cellular degeneration, and intranuclear viral particles suggesting papillomavirus infection in the keratinocytes were not observed. Papillomavirus antigen and DNA were not detected in the lesions by immunohistochemistry and polymerase chain reaction, respectively. In accordance with these clinical and histopathological features, the cutaneous lesions of the present cat were diagnosed as epidermal nevi, which were consistent with human inflammatory linear verrucous epidermal nevi.
对一只2岁雌性猫身上的多发性、色素沉着性、疣状皮肤病变进行了病理检查。病变呈线性排列于身体右侧，自幼年起就伴有中度瘙痒。组织学上，病变的特征为表皮显著的外生性、乳头瘤样增生以及棘层肥厚，并伴有明显的正角化和角化不全性角化过度。还观察到真皮有单核细胞、中性粒细胞和嗜酸性粒细胞浸润。未观察到提示角质形成细胞乳头瘤病毒感染的包涵体、细胞变性和核内病毒颗粒。通过免疫组织化学和聚合酶链反应分别在病变中未检测到乳头瘤病毒抗原和DNA。根据这些临床和组织病理学特征，该猫的皮肤病变被诊断为表皮痣，与人类炎症性线性疣状表皮痣相符。
