Singh Sanjay, Khandpur Sujay, Agarwal Shipra
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
BMJ Case Rep. 2018 Oct 17;2018:bcr-2018-225964. doi: 10.1136/bcr-2018-225964.
A 17-year-old woman presented with moderately itchy, non-progressive, linearly arranged verrucous plaques over dorsum of left foot since early childhood. Two years ago, she developed slowly increasing, verrucous exophytic growth in posterior most aspect of linear verrucous plaque. One year ago, she also developed multiple, linearly arranged, fleshy plaques with surface crusting over lateral aspect of right leg extending to thigh. Biopsy from both verrucous lesion on left foot and fleshy plaque on right leg showed an exophytic growth with significant papillomatosis, neutrophils in stratum corneum, acanthosis and infiltration of papillary dermis with foamy macrophages that were CD 68 positive, features compatible with verruciform xanthoma (VX). Biopsy from linear verrucous plaque over left foot was consistent with inflammatory linear verrucous epidermal nevus (ILVEN). A diagnosis of segmental VX and VX overlying ILVEN was made.
一名17岁女性自幼儿期起，左脚背出现中度瘙痒、非进行性、呈线性排列的疣状斑块。两年前，在这条线性疣状斑块的最后方出现了缓慢增大的疣状外生性肿物。一年前，她右腿外侧至大腿还出现了多个呈线性排列、表面结痂的肉质斑块。对左脚的疣状皮损和右腿的肉质斑块进行活检，结果显示为外生性肿物，伴有显著的乳头瘤病、角质层中性粒细胞浸润、棘层肥厚以及真皮乳头层有CD68阳性的泡沫状巨噬细胞浸润，这些特征符合疣状黄瘤（VX）。左脚线性疣状斑块的活检结果符合炎性线性疣状表皮痣（ILVEN）。最终诊断为节段性VX及ILVEN上覆VX。
