Department of Radiation Oncology, Selcuklu Faculty of Medicine, Selcuk University, Konya, Turkey.
Int J Gynecol Cancer. 2012 Jul;22(6):1096-101. doi: 10.1097/IGC.0b013e3182559c03.
Our aim was to evaluate the health-related quality of life (HRQoL) and psychological distress in patients treated with radiotherapy (RT) for gynecologic malignancy.
Fifty-seven women with either cervical or endometrial cancer were prospectively enrolled. We assessed HRQoL at baseline (after surgery before RT), at the end of RT, and during follow-up (every 3 months thereafter) using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire 30 (EORTC QLQ-C30), European Organization for Research and Treatment of Cervical Cancer Quality of Life Questionnaire 24 (EORTC QLQ-CX24), and Hospital Anxiety and Depression Scale.
We demonstrated changes in appetite loss (P = 0.03), nausea and vomiting (P = 0.02), and role function score (P = 0.003) domains of EORTC QLQ-C30. Only the mean body image score of EORTC QLQ-CX24 was significantly different during follow-up (P = 0.02). Type of surgery, histopathological diagnosis, and the menopausal and marital status of the patients affected baseline body image scores (P = 0.032, 0.004, and 0.019 and 0.005, respectively). Patients who underwent chemotherapy had higher baseline body image scores when compared with patients without any chemotherapy before RT (P = 0.028). All the complaints of patients except body image scores improved during the follow-up period. The baseline and follow-up anxiety and depression scores did not differ significantly.
Although pelvic RT deteriorated HRQoL in gynecologic cancer, patients' improvement in HRQoL during follow-up was observed. Patients receiving RT could be reassured about the improvement of acute adverse effects in the course of treatment.
评估妇科恶性肿瘤患者接受放射治疗（RT）后的健康相关生活质量（HRQoL）和心理困扰。
前瞻性纳入 57 例宫颈癌或子宫内膜癌患者。我们使用欧洲癌症研究与治疗组织生活质量问卷 30 版（EORTC QLQ-C30）、欧洲癌症研究与治疗组织宫颈癌生活质量问卷 24 版（EORTC QLQ-CX24）和医院焦虑抑郁量表（HADS）在基线（手术完成后 RT 前）、RT 结束时和随访期间（此后每 3 个月）评估 HRQoL。
我们观察到 EORTC QLQ-C30 的食欲丧失、恶心呕吐和角色功能评分的变化（P = 0.03、0.02 和 0.003）。EORTC QLQ-CX24 的平均体像评分仅在随访期间显著不同（P = 0.02）。手术类型、组织病理学诊断、患者的绝经状态和婚姻状况影响基线体像评分（P = 0.032、0.004、0.019 和 0.005）。与未接受任何化疗的患者相比，接受化疗的患者在 RT 前的基线体像评分更高（P = 0.028）。除体像评分外，所有患者的抱怨在随访期间均有所改善。基线和随访的焦虑和抑郁评分无显著差异。
尽管盆腔 RT 降低了妇科恶性肿瘤患者的 HRQoL，但在随访期间观察到患者的 HRQoL 有所改善。接受 RT 的患者可以放心，治疗过程中急性不良反应会得到改善。
