成人身高与冠心病风险：德黑兰血脂和血糖研究。
Adult height and risk of coronary heart disease: Tehran Lipid and Glucose Study.
机构信息
Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
J Epidemiol. 2012;22(4):348-52. doi: 10.2188/jea.je20110102. Epub 2012 Jun 2.
BACKGROUND
We assessed the relationship between height and coronary heart disease (CHD) in an urban population of Tehran.
METHODS
4110 participants of the Tehran Lipid and Glucose Study who were 40 years of age or older (1880 men and 2230 women; mean age, 55.1 and 53.0 years, respectively) and free of CHD at baseline were followed for a mean of 9.1 years. We used Cox proportional hazards regression to evaluate the risk of a first CHD event across height tertiles.
RESULTS
First CHD events occurred in 239 men and 172 women. The estimated crude HR (95% CI) for CHD events associated with an increment of 1 SD in height was 0.96 (0.28-3.33) in men and 0.84 (0.72-0.97) in women. After adjustment for age, the associations were no longer present. Further adjustment for other confounders had little impact on the results: the HR (95% CI) associated with an increase of 1 SD in height was 1.02 (0.87-1.20) in men and 0.82 (0.66-1.02) in women.
CONCLUSIONS
After adjustment for age, height was not associated with CHD incidence in men or women.
背景
我们评估了德黑兰城市人口中身高与冠心病（CHD）之间的关系。
方法
4110 名参加德黑兰血脂和血糖研究的参与者年龄在 40 岁或以上（男性 1880 人，女性 2230 人；平均年龄分别为 55.1 岁和 53.0 岁），基线时无 CHD。平均随访 9.1 年后，我们使用 Cox 比例风险回归来评估各身高三分位组发生首次 CHD 事件的风险。
结果
239 名男性和 172 名女性发生了首次 CHD 事件。与身高每增加 1 个标准差相关的 CHD 事件的估计粗 HR（95%CI）在男性中为 0.96（0.28-3.33），在女性中为 0.84（0.72-0.97）。调整年龄后，这种关联不再存在。进一步调整其他混杂因素对结果影响不大：与身高每增加 1 个标准差相关的 HR（95%CI）在男性中为 1.02（0.87-1.20），在女性中为 0.82（0.66-1.02）。
结论
在调整年龄后，身高与男性或女性的 CHD 发病率无关。
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