Burgess R E, Burgess V F, Dibella N J
JAMA. 1979 Nov 9;242(19):2084-6.
The records of 177 patients with small cell carcinoma of the lung were reviewed to determine parameters associated with brain metastases. Complete autopsy, including examination of the brain, was done in each case. Of the 70 cases of brain metastases, only two patients (3%) were aged 70 years or more as compared with 19 (18%) aged 70 years or more who did not have brain metastases. Patients with brain metastases had a longer median survival as compared with those without brain metastases. Patients with brain metastases had involvement of the thyroid and kidney more frequently (23% and 34%, respectively) compared with patients without brain metastases (8% and 13%). Thus, patients who have brain metastases tend to (1) be less than 70 years of age; (2) have a longer survival; and (3) have a higher incidence of metastases to the thyroid and kidney.
回顾了177例肺小细胞癌患者的记录，以确定与脑转移相关的参数。每例均进行了包括脑部检查在内的完整尸检。在70例脑转移病例中，只有2例患者（3%）年龄在70岁及以上，而未发生脑转移的患者中有19例（18%）年龄在70岁及以上。与无脑转移的患者相比，有脑转移的患者中位生存期更长。与无脑转移的患者（分别为8%和13%）相比，有脑转移的患者甲状腺和肾脏受累更为频繁（分别为23%和34%）。因此，发生脑转移的患者往往（1）年龄小于70岁；（2）生存期更长；（3）甲状腺和肾脏转移的发生率更高。
