Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
FEBS Lett. 2012 May 21;586(10):1504-9. doi: 10.1016/j.febslet.2012.04.007. Epub 2012 Apr 25.
It has been demonstrated that potassium channels (K(+) channels) play significant roles in some malignant phenotypes. Here, we provide the first evidence that treatment with glybenclamide, an ATP-sensitive K(+) channel blocker, inhibited cell migration in an ovarian clear cell carcinoma cell line, ES-2. Treatment with glybenclamide or knockdown by siRNA targeted against K(+) channel subunits demonstrated the suppression of ovarian cancer cell invasion, which occurred via inhibition of PDGF-AA secretion. Therefore, our findings suggest that K(+) channel blockers may be useful chemotherapeutic drugs for blocking the invasiveness of ovarian cancers.
已有研究表明，钾通道（K(+) 通道）在某些恶性表型中发挥着重要作用。在这里，我们首次提供证据表明，ATP 敏感性 K(+) 通道阻滞剂格列本脲治疗可抑制卵巢透明细胞癌细胞系 ES-2 中的细胞迁移。用格列本脲处理或用针对 K(+) 通道亚基的 siRNA 敲低，可抑制卵巢癌细胞侵袭，这是通过抑制 PDGF-AA 分泌来实现的。因此，我们的研究结果表明，K(+) 通道阻滞剂可能是用于阻断卵巢癌侵袭性的有用化疗药物。
