Troyanovsky Sergey
Department of Dermatology, Feinberg School of Medicine, Northwestern University, 60611, Chicago, IL, USA,
Subcell Biochem. 2012;60:89-108. doi: 10.1007/978-94-007-4186-7_5.
Classical cadherins are a family of transmembrane proteins that mediate cell-cell adhesion at adherens junctions. A complex chain of cis- and trans- interactions between cadherin ectodomains establishes a cadherin adhesive cluster. A principal adhesive interaction in such clusters is an exchange of β strands between the first extracellular cadherin domains (EC1). The structure of cadherin adhesive clusters can be modified by other adherens junction proteins including additional transmembrane proteins, nectins and various intracellular proteins that directly or indirectly interact with the intracellular cadherin region. These interactions determine the dynamics and stability of cadherin adhesive structures.
经典钙黏蛋白是一类跨膜蛋白，可介导黏着连接中的细胞间黏附。钙黏蛋白胞外结构域之间复杂的顺式和反式相互作用链形成了一个钙黏蛋白黏附簇。此类簇中的主要黏附相互作用是第一个细胞外钙黏蛋白结构域（EC1）之间β链的交换。钙黏蛋白黏附簇的结构可被其他黏着连接蛋白修饰，包括其他跨膜蛋白、nectins以及各种与细胞内钙黏蛋白区域直接或间接相互作用的细胞内蛋白。这些相互作用决定了钙黏蛋白黏附结构的动力学和稳定性。
