使用石英晶体微天平生物传感器研究完整细胞上的转移标志物。
Using a quartz crystal microbalance biosensor for the study of metastasis markers on intact cells.
作者信息
Saint-Guirons Julien, Ingemarsson Björn
机构信息
R&D Department, DHR Finland Oy, Innotrac Diagnostics, Turku, Finland.
出版信息
Methods Mol Biol. 2012;878:175-83. doi: 10.1007/978-1-61779-854-2_11.
The use of biosensors has become a standard method to characterize biomolecular interactions. Data obtained from biosensor studies are widely used to evaluate drug candidates, particularly in relation to their binding properties towards a selected target. The importance of measuring such interactions in a biologically relevant environment has become the new challenge for the biosensor technologies. In this chapter we describe a method for studying interactions between proteins and targets at the surface of intact cells using a quartz crystal microbalance (QCM) biosensor.
生物传感器的使用已成为表征生物分子相互作用的标准方法。从生物传感器研究中获得的数据被广泛用于评估候选药物，尤其是关于它们对选定靶点的结合特性。在生物相关环境中测量此类相互作用的重要性已成为生物传感器技术面临的新挑战。在本章中，我们描述了一种使用石英晶体微天平（QCM）生物传感器研究完整细胞表面蛋白质与靶点之间相互作用的方法。
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