如何使用国际药理学联合会（IUPHAR）受体数据库浏览药理学数据。

How to use the IUPHAR receptor database to navigate pharmacological data.

作者信息

Mpamhanga Chidochangu P, Sharman Joanna L, Harmar Anthony J

机构信息

University/BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.

出版信息

Methods Mol Biol. 2012;897:15-29. doi: 10.1007/978-1-61779-909-9_2.

DOI:10.1007/978-1-61779-909-9_2

PMID:22674159

Abstract

Today's data-intensive, interdisciplinary research challenges scientists to keep up to date with key experimental techniques and tools reported in the literature. The International Union of Basic and Clinical Pharmacology Database (IUPHAR-DB) goes some way to addressing this need by providing expert-curated information sourced from primary literature and displayed in a user-friendly manner online. The database provides a channel for the IUPHAR Nomenclature Committee (NC-IUPHAR) to provide recommendations on the nomenclature of receptors and ion channels, to document their properties and the ligands that are useful for receptor characterization. Here we describe IUPHAR-DB's main features and provide examples of techniques for navigating and exploring the information. The database is freely available online at http://www.iuphar-db.org/.

摘要

当今数据密集型的跨学科研究对科学家提出了挑战，要求他们跟上文献中报道的关键实验技术和工具的最新进展。国际基础与临床药理学联合会数据库（IUPHAR-DB）通过提供从原始文献中精心挑选的信息，并以用户友好的方式在线展示，在一定程度上满足了这一需求。该数据库为IUPHAR命名委员会（NC-IUPHAR）提供了一个渠道，以就受体和离子通道的命名提供建议，记录它们的特性以及对受体表征有用的配体。在这里，我们描述IUPHAR-DB的主要特征，并提供浏览和探索信息的技术示例。该数据库可在http://www.iuphar-db.org/免费在线获取。