Alexander Stephen P H, Benson Helen E, Faccenda Elena, Pawson Adam J, Sharman Joanna L, Catterall William A, Spedding Michael, Peters John A, Harmar Anthony J
School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
Br J Pharmacol. 2013 Dec;170(8):1607-51. doi: 10.1111/bph.12447.
The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full. Ion channels are one of the seven major pharmacological targets into which the Guide is divided, with the others being G protein-coupled receptors, ligand-gated ion channels, catalytic receptors, nuclear hormone receptors, transporters and enzymes. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. A new landscape format has easy to use tables comparing related targets. It is a condensed version of material contemporary to late 2013, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in previous Guides to Receptors and Channels. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and the Guide to Receptors and Channels, providing a permanent, citable, point-in-time record that will survive database updates.
《2013/14药理学简明指南》简要概述了2000多种人类药物靶点的关键特性及其药理学,还提供了与药物靶点及其配体的开放获取知识库(www.guidetopharmacology.org)的链接,该知识库提供了靶点和配体特性的更详细视图。完整内容可在http://onlinelibrary.wiley.com/doi/10.1111/bph.12444/full查阅。离子通道是该指南划分的七个主要药理学靶点之一,其他靶点包括G蛋白偶联受体、配体门控离子通道、催化受体、核激素受体、转运体和酶。这些内容配有命名指南以及关于最佳可用药理学工具的总结信息,还有关键参考文献和进一步阅读建议。一种新的页面布局形式有便于使用的表格,可比较相关靶点。它是2013年末当代资料的精简版,在网站www.guidetopharmacology.org上有更详细的呈现且不断更新,取代了之前《受体与通道指南》中的数据。它是与NC - IUPHAR联合编写的,在适当情况下提供人类药物靶点的官方IUPHAR分类和命名。它整合了之前在IUPHAR - DB以及《受体与通道指南》中分别整理和展示的信息,提供了一份永久性的、可引用的、特定时间点的记录,即便数据库更新也依然存在。