Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India.
Cancer Biomark. 2011;10(3-4):125-34. doi: 10.3233/CBM-2012-0238.
The over expression of LL37, an antimicrobial peptide belonging~to the cathelicidin family has implication in the progression of human malignancy but the exact role is still not clear. This study aims to elucidate the correlation of LL37 with Head and Neck Squamous Cell Carcinoma (HNSCC) and the consequences of radiotherapy on it. The LL37 levels were quantified in serum samples of control and HNSCC patients at pre-RT, during-RT and post-RT using a real time Surface Plasmon Resonance technology and ELISA. The LL37 of 50 HNSCC patients was significantly (p < 0.0001) threefold higher than the 25 controls and declined with respect to radiation therapy (p < 0.0001) supporting its candidature as a prognostic marker in HNSCC.
LL37 是一种属于抗菌肽家族的抗菌肽，其过度表达与人类恶性肿瘤的进展有关，但确切的作用尚不清楚。本研究旨在阐明 LL37 与头颈部鳞状细胞癌（HNSCC）的相关性，以及放疗对其的影响。使用实时表面等离子体共振技术和 ELISA 定量检测对照组和 HNSCC 患者在放疗前、放疗期间和放疗后的血清样本中的 LL37 水平。50 例 HNSCC 患者的 LL37 明显（p<0.0001）高于 25 例对照组，且随着放疗而下降（p<0.0001），支持其作为 HNSCC 预后标志物的候选物。
