Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Science. 2012 Jun 8;336(6086):1262-7. doi: 10.1126/science.1223813. Epub 2012 Jun 6.
The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.
肠道微生物组的组成和活性与宿主一起从出生开始发展，并受到复杂的相互作用的影响，这些相互作用取决于宿主的基因组、营养和生活方式。肠道微生物组参与调节多种宿主代谢途径，形成了相互作用的宿主-微生物代谢、信号和免疫炎症轴，这些轴在生理上连接着肠道、肝脏、肌肉和大脑。深入了解这些轴是优化治疗策略以操纵肠道微生物组来对抗疾病和改善健康的前提。
