Center for Magnetic Resonance Research, Radiology, University of Minnesota, Minneapolis, MN 55455, USA.
NMR Biomed. 2013 Jan;26(1):51-7. doi: 10.1002/nbm.2818. Epub 2012 Jun 7.
Prostate perfusion has the potential to become an important pathophysiological marker for the monitoring of disease progression or the assessment of the therapeutic response of prostate cancer. The feasibility of arterial spin labeling, an MRI approach for the measurement of perfusion without an exogenous contrast agent, is demonstrated in the prostate for the first time. Although various arterial spin labeling methods have been demonstrated previously in highly perfused organs, such as the brain and kidneys, the prospect of obtaining such measurements in the prostate is challenging because of the relatively low blood flow, long transit times, susceptibility-induced image distortion and local motion. However, despite these challenges, this study demonstrates that, with a whole-body transmit coil and external receiver array, global prostate perfusion can be measured with arterial spin labeling at 3 T. In five healthy subjects with a mean age of 44 years, the mean total prostate blood flow was measured to be 25.8 ± 7.1 mL/100 cm(3) /min, with an estimated bolus duration and arterial transit time of 884 ± 209 ms and 721 ± 131 ms, respectively.
前列腺灌注有可能成为监测疾病进展或评估前列腺癌治疗反应的重要病理生理学标志物。首次在前列腺中证明了动脉自旋标记（一种无需外源性造影剂即可测量灌注的 MRI 方法）的可行性。虽然之前已经在高灌注器官（如大脑和肾脏）中证明了各种动脉自旋标记方法，但由于血流相对较低、传输时间较长、感应引起的图像失真和局部运动，在前列腺中获得此类测量值的前景具有挑战性。然而，尽管存在这些挑战，本研究表明，使用全身发射线圈和外部接收阵列，在 3 T 下可以用动脉自旋标记测量整个前列腺的灌注。在 5 名平均年龄为 44 岁的健康受试者中，平均总前列腺血流量为 25.8 ± 7.1 mL/100 cm(3) /min，估计的团注持续时间和动脉传输时间分别为 884 ± 209 ms 和 721 ± 131 ms。
