Camargos Einstein Francisco, Quintas Juliana Lima
Geriatric Medical Centre, University Hospital, Brasilia University, Brasília, Distrito Federal, Brazil.
BMJ Case Rep. 2011 Nov 15;2011:bcr0820114652. doi: 10.1136/bcr.08.2011.4652.
The treatment of apathy is often complicated and difficult. The authors present a case of apathy syndrome that was treated successfully with modafinil. An 87-year-old widowed Brazilian woman presented with loss of interest and pleasure in activities. Her level of apathy, as evaluated by the Brazilian care giver version of the apathy scale, was 25 (a score higher than 18 points is associated with an apathy syndrome). No diagnosis of depression or sleep disorder was noted. After 2 years with many different antidepressants, modafinil treatment was started at 100 mg/day. One month after the initiation of modafinil therapy, the patient reported feeling more motivation, and she also returned to her favorite physical activity, which was swimming (400 m/day). Apathy scale revealed an improvement (18 points). Actigraphic analysis was performed, and no sleep disturbances were noted before or after treatment. Modafinil may be a promising option in the treatment of apathy.
淡漠的治疗通常复杂且困难。作者介绍了一例使用莫达非尼成功治疗的淡漠综合征病例。一名87岁的巴西丧偶女性表现出对活动失去兴趣和愉悦感。根据巴西护理人员版淡漠量表评估，她的淡漠程度为25分（得分高于18分与淡漠综合征相关）。未发现抑郁症或睡眠障碍的诊断。在使用多种不同抗抑郁药治疗两年后，开始使用莫达非尼，剂量为100毫克/天。莫达非尼治疗开始一个月后，患者报告感觉更有动力，并且她还恢复了最喜欢的体育活动——游泳（每天400米）。淡漠量表显示有所改善（18分）。进行了活动记录仪分析，治疗前后均未发现睡眠障碍。莫达非尼可能是治疗淡漠的一个有前景的选择。
