Centro Oncologico Veterinario, Sasso Marconi, Italy.
Hematol Oncol. 2013 Mar;31(1):1-9. doi: 10.1002/hon.2017. Epub 2012 Jun 6.
Lymphoma represents the most frequent hematopoietic cancer in dogs, and it shows significant overlap with the human disease. Several environmental factors have been associated with canine lymphoma, suggesting that they may contribute to lymphomagenesis. Canine lymphoma often presents in advanced stage (III-V) at diagnosis and, most commonly, has an aggressive clinical course requiring prompt treatment, which relies on the use of polychemotherapy. In this review, we will summarize the state-of-the-art of canine lymphoma epidemiology, pathobiology, diagnostic work-up and therapy, and will highlight the links to the corresponding human disease, providing evidence for the use of dog as an animal model of spontaneous disease.
淋巴瘤是犬类最常见的血液系统恶性肿瘤，与人类疾病有很大的重叠。有几种环境因素与犬淋巴瘤有关，这表明它们可能有助于淋巴瘤的发生。犬淋巴瘤通常在诊断时已处于晚期（III-V 期），且大多数情况下具有侵袭性临床病程，需要及时治疗，这依赖于多化疗的应用。在本综述中，我们将总结犬淋巴瘤的流行病学、病理生物学、诊断和治疗的最新进展，并强调与相应人类疾病的联系，为将犬作为自发性疾病的动物模型提供证据。
