Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr, Germany.
Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6929-33. doi: 10.1002/anie.201203180. Epub 2012 Jun 4.
Treat me gently: for a selective synthesis of the unusually sensitive cyclophanic α-pyrone neurymenolide A, the chosen catalysts must be able to distinguish between six different sites of unsaturation, without scrambling any of the skipped π systems. This challenge was met with a new gold-catalyzed pyrone synthesis in combination with a molybdenum-catalyzed ring-closing alkyne metathesis.
为了选择性合成异常敏感的环状α-吡酮神经美灵 A，所选的催化剂必须能够区分六个不同的不饱和位点，而不会扰乱任何跳过的π系统。这一挑战通过一种新的金催化吡喃合成与钼催化的环闭炔烃复分解反应相结合来实现。
