Guedes Rita, Leite Inês, Baptista Armando, Rocha Natividade
Dermatology Department, Centro Hospitalar de Vila Nova de Gaia Espinho, Rua Conceição Fernandes, 4434-502 Vila Nova de Giaa, Portugal.
Case Rep Med. 2012;2012:854738. doi: 10.1155/2012/854738. Epub 2012 May 23.
Necrobiosis lipoidica is a rare granulomatous and inflammatory disease. Its management is particularly difficult when ulceration is present. The authors describe the clinical case of a 65-year-old female patient with necrobiosis lipoidica, who had been submitted in the past to several topical and systemic treatments with little or no improvement. She started treatment with subcutaneous etanercept and showed significant improvement without adverse events until today. The aim of this article is to report a valid and efficient alternative treatment to recalcitrant cases.
类脂质渐进性坏死是一种罕见的肉芽肿性炎症性疾病。当出现溃疡时，其治疗尤为困难。作者描述了一例65岁患有类脂质渐进性坏死的女性患者的临床病例，该患者过去曾接受过多种局部和全身治疗，但改善甚微或没有改善。她开始接受皮下注射依那西普治疗，至今显示出显著改善且无不良事件。本文的目的是报告一种针对难治性病例的有效替代治疗方法。
