Faculty of Veterinary Science, The University of Melbourne, Werribee, Vic., Australia.
J Vet Intern Med. 2012 Jul-Aug;26(4):875-87. doi: 10.1111/j.1939-1676.2012.00949.x. Epub 2012 Jun 7.
The cellular events leading to pancreatitis have been studied extensively in experimental models. Understanding the cellular events and inciting causes of the multisystem inflammatory cascades that are activated with this disease is of vital importance to advance diagnosis and treatment of this condition. Unfortunately, the pathophysiology of pancreatitis in dogs is not well understood, and extrapolation from experimental and human medicine is necessary. The interplay of the inflammatory cascades (kinin, complement, cytokine) is extremely complex in both initiating leukocyte migration and perpetuating disease. Recently, nitric oxide (NO) and altered microcirculation of the pancreas have been proposed as major initiators of inflammation. In addition, the role of the gut is becoming increasingly explored as a cause of oxidative stress and potentiation of systemic inflammation in pancreatitis.
导致胰腺炎的细胞事件已在实验模型中进行了广泛研究。了解这种疾病激活的多系统炎症级联反应的细胞事件和引发原因，对于推进这种疾病的诊断和治疗至关重要。不幸的是，犬胰腺炎的病理生理学尚未得到很好的理解，因此需要从实验和人类医学中进行推断。炎症级联（激肽、补体、细胞因子）在启动白细胞迁移和持续疾病方面的相互作用非常复杂。最近，一氧化氮（NO）和胰腺微循环的改变被认为是炎症的主要启动因素。此外，肠道的作用作为氧化应激和胰腺炎全身炎症增强的原因，正越来越受到关注。
