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用于构建可控性皮尿袋的浆膜衬里单向活瓣:时间的考验。

Serous-lined unidirectional valve for construction of continent cutaneous urinary reservoir: the test of time.

机构信息

Mansoura Urology and Nephrology Center, Mansoura University, Egypt.

出版信息

Urology. 2012 Aug;80(2):452-8. doi: 10.1016/j.urology.2012.02.068. Epub 2012 Jun 5.

Abstract

OBJECTIVE

To assess the long-term outcome of using the serous-lined extramural tunnel technique for construction of continent-cutaneous urinary reservoir in an objective way.

METHODS

Cases that were operated until the end of 2003 and were eligible for evaluation at the time of the study were included. Continence, upper tract status, and complications were the targets of evaluation. Clear definition of continence was used, and biochemical kidney function profile was assessed with calculation of estimated glomerular filtration rate (eGFR) as a measure of the overall renal function in addition to the standard radiological assessment tools. A modified Clavien scale was followed for grading of complications.

RESULTS

After a median of 121.3 months, the final continence rate was 91.1%. Maintained upper tract status was in almost 96.6% of cases and stricture of ureterointestinal anastomosis (UIA) was diagnosed in 3 renal units, and ureteral reflux was diagnosed in 24 renal units. Biochemical kidney function profile showed mean percent reduction of total eGFR to be 14.2%, and 3 patients had ≥50% reduction of total eGFR. On the Clavien scale, low-grade complications (GI-II) occurred in 30 patients (33%) and high-grade complications (≥GIII) occurred in 36 patients (40%). Stoma complications were the most frequent complications. At last follow-up, 42 patients (47%) were free of complications.

CONCLUSION

The serous-lined extramural valve is an efficient technique for maintaining unidirectional flow. Over a decade, good functional outcome of the cutaneous reservoir has been evident. However, with a clear definition of continence and objective assessment of the outcome, at least one third of patients will have high-grade complications, with excellent reintervention outcome maintaining efficacy of the technique.

摘要

目的

客观评估使用浆膜层外隧道技术构建可控性尿流改道术的长期效果。

方法

纳入直至 2003 年底接受手术且在研究时适合评估的病例。评估指标包括控尿、上尿路情况和并发症。控尿采用明确定义,生化肾功能采用估算肾小球滤过率(eGFR)评估,以评估整体肾功能,同时还采用标准影像学评估工具。并发症分级采用改良 Clavien 分级。

结果

中位随访 121.3 个月后,最终控尿率为 91.1%。几乎 96.6%的病例保持了上尿路情况,3 个肾单位诊断为输尿管-肠吻合口狭窄,24 个肾单位诊断为输尿管反流。生化肾功能显示总 eGFR 平均下降 14.2%,3 例患者总 eGFR 下降≥50%。根据 Clavien 分级,30 例(33%)发生低级别(GI-II)并发症,36 例(40%)发生高级别(≥GIII)并发症。造口并发症最常见。末次随访时,42 例(47%)患者无并发症。

结论

浆膜层外瓣是一种维持单向流动的有效技术。10 多年来,尿流改道皮肤储尿囊的功能结果良好。然而,通过明确的控尿定义和客观的结果评估,至少有三分之一的患者会发生高级别并发症,但良好的再次干预结果维持了该技术的疗效。

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