Myers Jeremy B, Mayer Erik N, Lenherr Sara
The Center for Reconstructive Urology, Department of Surgery, University of Utah, Salt Lake City, Utah, USA.
Transl Androl Urol. 2016 Feb;5(1):145-57. doi: 10.3978/j.issn.2223-4683.2015.12.11.
Neurogenic bladder is a very broad disease definition that encompasses varied disease and injury states affecting the bladder. The majority of patients with neurogenic bladder dysfunction do not have concomitant intrinsic sphincteric deficiency (ISD), but when this occurs the challenges of management of urinary incontinence from neurogenic bladder are compounded. There are no guidelines for surgical correction of ISD in adults and most of the literature on treatment of the problem comes from treatment of children with congenital diseases, such as myelomeningocele. Our goal, in this review, is to present some of the common surgical options for ISD [including artificial urinary sphincters, bladder slings, bladder neck reconstruction (BNR) and urethral bulking agents] and the evidence underlying these treatments in adults with neurogenic bladder.
神经源性膀胱是一个非常宽泛的疾病定义,涵盖了影响膀胱的各种疾病和损伤状态。大多数神经源性膀胱功能障碍患者并无伴发的固有括约肌缺陷(ISD),但当出现这种情况时,神经源性膀胱所致尿失禁的管理挑战就会变得更加复杂。目前尚无针对成人ISD手术矫正的指南,且关于该问题治疗的大多数文献都来自对患有先天性疾病(如脊髓脊膜膨出)儿童的治疗。在本综述中,我们的目标是介绍ISD的一些常见手术选择[包括人工尿道括约肌、膀胱吊带、膀胱颈重建(BNR)和尿道填充剂]以及这些治疗方法在成人神经源性膀胱患者中的证据基础。