Wiesner Christoph, Pahernik Sascha, Stein Raimund, Hähn Katja, Franzaring Ludger, Melchior Sebastian W, Thüroff Joachim W
Department of Urology, Johannes Gutenberg-University, School of Medicine, Mainz, Germany.
BJU Int. 2007 Sep;100(3):633-7. doi: 10.1111/j.1464-410X.2007.06991.x. Epub 2007 May 19.
To assess upper urinary tract complications and renal function in patients with a submucosal tunnel and serosa-lined extramural tunnel ureter implantation during the long-term follow-up of ileocaecal continent cutaneous urinary diversion (Mainz pouch I).
In all, 458 patients who had diversion with the ileocaecal pouch were analysed in a retrospective follow-up study. Uretero-intestinal implantation was done using a submucosal tunnel (ST) in 809 reno-ureteric units (RUs) and by the serosa-lined extramural tunnel (ET) technique in 74 RUs. The median age of the patients at the time of surgery was 47.1 years, and the median follow-up was 89.0 months.
For the ST, there was anastomotic obstruction in 59 RUs (7.3%) at a median of 16.8 months after diversion; the obstruction-free intervals at 1, 5 and 10 years were 97%, 93% and 91%, respectively. Obstruction rates were 13.9% for previously dilated upper tracts and 17.1% in patients with a neurogenic bladder. Serum creatinine levels were < or =1.6 mg/dL in 97% of the patients at the latest follow-up. For ET, there was anastomotic obstruction in three RUs (4.1%) at a median of 17.2 months after diversion. Obstruction-free intervals at 1, 5 and 10 years were 100%, 96% and 96%. Preoperative dilation of the upper tracts did not reduce the obstruction rate (3.1%), but it was 7.1% in patients with a neurogenic bladder. Serum creatinine levels were < or =1.6 mg/dL in 98% of the patients at the latest follow-up.
The ET gives lower obstruction rates than the ST, especially when upper tracts are dilated and in patients with a neurogenic bladder. Renal function remained stable with both techniques in the long term.
在回盲部可控性皮肤造口尿流改道术( Mainz I 型贮尿囊)的长期随访中,评估采用黏膜下隧道及浆膜衬里壁外隧道输尿管植入术患者的上尿路并发症及肾功能。
在一项回顾性随访研究中,对458例行回盲部贮尿囊尿流改道的患者进行了分析。809个肾输尿管单位(RU)采用黏膜下隧道(ST)进行输尿管肠植入,74个RU采用浆膜衬里壁外隧道(ET)技术。手术时患者的中位年龄为47.1岁,中位随访时间为89.0个月。
对于ST,59个RU(7.3%)在尿流改道后中位16.8个月出现吻合口梗阻;1年、5年和10年的无梗阻间期分别为97%、93%和91%。既往上尿路扩张患者的梗阻率为13.9%,神经源性膀胱患者的梗阻率为17.1%。在最近一次随访时,97%的患者血清肌酐水平≤1.6mg/dL。对于ET,3个RU(4.1%)在尿流改道后中位17.2个月出现吻合口梗阻。1年、5年和10年的无梗阻间期分别为100%、96%和96%。术前上尿路扩张并未降低梗阻率(3.1%),但神经源性膀胱患者的梗阻率为7.1%。在最近一次随访时,98%的患者血清肌酐水平≤1.6mg/dL。
ET的梗阻率低于ST,尤其是在上尿路扩张的患者及神经源性膀胱患者中。两种技术长期来看肾功能均保持稳定。