Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Vet Parasitol. 2012 Nov 23;190(1-2):289-93. doi: 10.1016/j.vetpar.2012.05.008. Epub 2012 May 19.
Ancylostoma ceylanicum is a common zoonotic hookworm of dogs and cats, especially in the Asia-Pacific region. The objective of this study was to determine the efficacy of a spot on combination product containing imidacloprid 10% and moxidectin 1% (Advocate(®)/Advantage(®) Multi, Bayer Animal Health) against A. ceylanicum in experimentally infected cats. Sixteen kittens were each subcutaneously injected with 100 infective third-stage larvae of A. ceylanicum. Kittens were stratified by egg count and randomly allocated into control and treatment groups. The kittens in the treatment group were each treated with a spot on combination of 10% (w/v) imidacloprid and 1% (w/v) moxidectin, administered topically at recommended label dose rates. The kittens in the control group were not treated. Egg counts were performed daily until the end of the study period and compared for the treated and control groups. No eggs were detected in the treated group of kittens within 4 days of treatment and faecal samples from this group remained negative throughout the rest of the study, resulting in a treatment efficacy (egg reduction) of 100% (P<0.0001). The egg counts remained high (993 ± 666 epg) in the untreated control group for the rest of the study period. This study demonstrated that based on faecal egg count reduction, the spot on combination containing imidacloprid 10% (w/v) and moxidectin 1% (w/v) (Advocate(®)/Advantage(®) Multi, Bayer Animal Health) given at the recommended dose is highly effective against infection with A. ceylanicum in cats.
锡兰钩口线虫是一种常见的犬猫动物源性钩虫，尤其在亚太地区较为常见。本研究的目的是评估含有 10%吡虫啉和 1%莫昔克丁的透皮溶液（Advocate®/Advantage® Multi，拜耳动保）对实验感染猫锡兰钩口线虫的疗效。16 只幼猫均经皮下注射 100 条感染性第三期幼虫锡兰钩口线虫。根据卵计数将幼猫分层，并随机分为对照组和治疗组。治疗组的每只猫均以推荐标签剂量的 10%（w/v）吡虫啉和 1%（w/v）莫昔克丁的透皮溶液进行局部治疗。对照组的猫未进行治疗。每天进行卵计数，直至研究结束，并比较治疗组和对照组的结果。治疗组的猫在治疗后 4 天内未检测到卵，且整个研究期间粪便样本均为阴性，治疗效果（卵减少）为 100%（P<0.0001）。未治疗的对照组猫在研究期间其余时间内的卵计数仍很高（993 ± 666 epg）。本研究表明，基于粪便卵计数减少，以推荐剂量使用的含有 10%吡虫啉（w/v）和 1%莫昔克丁（w/v）的透皮溶液（Advocate®/Advantage® Multi，拜耳动保）对猫感染锡兰钩口线虫非常有效。
