Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Vet Parasitol. 2013 Jan 16;191(1-2):172-6. doi: 10.1016/j.vetpar.2012.08.024. Epub 2012 Sep 4.
Ancylostoma ceylanicum is a common zoonotic hookworm of dogs and cats throughout Asia and has also been reported to occur within the Australasian region. The aim of this study to was to determine the efficacy of a spot-on formulation containing emodepside and praziquantel (Profender(®), Bayer) and praziquantel and pyrantel oral tablets (Drontal(®) for Cats, Bayer) against experimental A. ceylanicum infections in cats. Twenty-four kittens were each subcutaneously injected with 100 infective third-stage larvae of A. ceylanicum. Kittens were stratified by egg count and randomly allocated equally into control and two treatment groups. The first group were treated with emodepside 2.1%/praziquantel 8.6% (Profender®, Bayer) at the recommended label dose. The second group was treated with 80 mg pyrantel and 20mg praziquantel (Drontal(®) for Cats, Bayer) at the recommended label dose. The kittens in the control group were not treated. Egg counts were performed daily until the end of the study period and compared for the treated and control groups. No eggs were detected in the treated group of kittens within 4 days of treatment and faecal samples from this group remained negative throughout the rest of the study, resulting in a treatment efficacy (egg reduction) of 100% (P<0.0001). The egg counts remained high (993 ± 666 epg) in the untreated control group for the rest of the study period. This study demonstrated that both combination products containing topical emodepside/praziquantel (Profender(®), Bayer) and praziquantel/pyrantel oral tablets (Drontal(®) for Cats, Bayer) given at the recommended dose is highly effective against infection with A. ceylanicum in cats.
犬猫体内常见的亚洲地区共生钩虫Ancylostoma ceylanicum 也已在澳大拉西亚地区报告发生。本研究旨在确定含有埃莫德昔（emodepside）和吡喹酮（praziquantel）（Profender（®），拜耳）的局部制剂和吡喹酮与双羟萘酸噻嘧啶（praziquantel and pyrantel）口服片剂（Drontal（®）for Cats，拜耳）对猫实验性Ancylostoma ceylanicum 感染的疗效。24 只小猫均经皮下注射 100 条感染性第三期幼虫 Ancylostoma ceylanicum。根据卵计数对小猫进行分层，并将其随机均等地分为对照组和两个治疗组。第一组用埃莫德昔 2.1%/吡喹酮 8.6%（Profender（®），拜耳）按推荐标签剂量进行治疗。第二组用 80mg 双羟萘酸噻嘧啶和 20mg 吡喹酮（Drontal（®）for Cats，拜耳）按推荐标签剂量进行治疗。对照组的小猫未进行治疗。在研究期间结束之前每天进行卵计数，并对治疗组和对照组进行比较。治疗组小猫在治疗后 4 天内未检测到卵，且该组粪便样本在研究其余时间内均呈阴性，这导致治疗有效率（卵减少）达到 100%（P<0.0001）。未治疗的对照组小猫的卵计数在研究其余时间内仍很高（993±666 epg）。本研究表明，在推荐剂量下使用含有局部埃莫德昔/吡喹酮（Profender（®），拜耳）和吡喹酮/双羟萘酸噻嘧啶口服片剂（Drontal（®）for Cats，拜耳）的两种组合产品对猫体内感染 Ancylostoma ceylanicum 非常有效。
