Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
Trends Immunol. 2012 Aug;33(8):413-20. doi: 10.1016/j.it.2012.04.010. Epub 2012 Jun 5.
The immune system has evolved into two main arms: the primitive innate arm that is the first line of defense but relatively short-lived and broad acting; and the advanced adaptive arm that generates immunological memory, allowing rapid, specific recall responses. T cell-independent type-2 (TI-2) antigens (Ags) invoke innate immune responses. However, due to its 'at the ready' nature, how the innate arm of the immune system maintains tolerance to potentially abundant host TI-2 Ags remains elusive. Therefore, it is important to define the mechanisms that establish innate immune tolerance. This review highlights recent insights into B cell tolerance to theoretical self TI-2 Ags, and examines how the B cell-restricted sialic acid binding Ig-like lectins (Siglecs), CD22 and Siglec-G, might contribute to this process.
原始的先天分支，是第一道防线，但相对寿命短且作用广泛；以及先进的适应性分支，它产生免疫记忆，允许快速、特异性的回忆反应。T 细胞非依赖性 2 型（TI-2）抗原（Ag）引发先天免疫反应。然而，由于其“随时待命”的性质，免疫系统的先天分支如何对潜在丰富的宿主 TI-2 Ag 保持耐受仍然难以捉摸。因此，确定建立先天免疫耐受的机制非常重要。这篇综述强调了最近对理论上自身 TI-2 Ag 中 B 细胞耐受的新认识，并探讨了 B 细胞限制性唾液酸结合免疫球蛋白样凝集素（Siglec）CD22 和 Siglec-G 如何有助于这一过程。
