Shchul'kin A V
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(2):35-9.
Effect of mexidol on the development of the phenomenon of the excitotoxic syndrome in vitro has been studied. Mexidol inhibits in vitro the development of glutamate-induced neurotoxicity, ascorbate-dependent (non-enzymatic) and NADPH₂-dependent (enzymatic) iron-induced lipid peroxide oxidation, is able in high concentrations to bind superoxide anion-radical, significantly increases the activity of Se-dependent glutathione peroxidase, decreases the activity of induced NO-synthase and does not impact on the activity of glutathione-SH-transferase, catalase and neuronal NO-synthase. These effects underlie the antioxidant and antihypoxic action of the drug.
已研究了美西律对体外兴奋性毒性综合征现象发展的影响。美西律在体外可抑制谷氨酸诱导的神经毒性、抗坏血酸依赖性（非酶促）和NADPH₂依赖性（酶促）铁诱导的脂质过氧化反应，在高浓度时能够结合超氧阴离子自由基，显著提高硒依赖性谷胱甘肽过氧化物酶的活性，降低诱导型一氧化氮合酶的活性，且不影响谷胱甘肽-SH-转移酶、过氧化氢酶和神经元型一氧化氮合酶的活性。这些作用构成了该药物的抗氧化和抗缺氧作用基础。
