Maruta N A, Rachkauskas G S, Frolov V M, Vysochin E V
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(3 Pt 1):31-3.
We studied 73 patients with paranoid schizophrenia with resistance to neuroleptics. All patients were divided into two groups - basic (37 patients) and comparison (36 patients). Both groups received traditional treatment. Patients of the basic group were treated with the combination of reamberin and cycloferon. Before treatment, significant alterations in the interferon status (IFS), which were characterized by the decrease of serum interferon (SIFN) activity and blood α- and γ-interferons (IFN) levels, were identified in both group. The positive effect of the drug combination on clinical symptoms and interferon status (the normalization of SIFN activity, increase in blood α- and γ-IFN levels) was found.
我们研究了73例对神经阻滞剂耐药的偏执型精神分裂症患者。所有患者被分为两组——基础组（37例患者）和对照组（36例患者）。两组均接受传统治疗。基础组患者接受雷美替胺和环磷酰胺的联合治疗。治疗前，两组均发现干扰素状态（IFS）有显著改变，其特征为血清干扰素（SIFN）活性降低以及血液α-和γ-干扰素（IFN）水平降低。发现该药物组合对临床症状和干扰素状态有积极作用（SIFN活性恢复正常，血液α-和γ-IFN水平升高）。
