Department of Medical Sciences, Respiratory Medicine and Allergology, Uppsala University and Centre for Research and Development, Uppsala University/County Council of Gävleborg, SE 801 88 Gävle, Sweden.
J Breath Res. 2012 Dec;6(4):047103. doi: 10.1088/1752-7155/6/4/047103. Epub 2012 Jun 7.
Extended NO analysis is a promising tool in different diseases where NO metabolism is altered. One single exhalation cannot give insight to the NO production in the respiratory system; rather the use of multiple exhalation flows can give the alveolar levels (C(A)NO), airway wall concentration (C(aw)NO) and the diffusion rate of NO (D(aw)NO). Increased values of C(A)NO are shown in COPD, systemic sclerosis, hepatopulmonary syndrome and in severe asthma. In asthma the C(aw)NO and D(aw)NO are increased leading to an increase in bronchial NO flux (J'(aw)NO). Low levels of J'(aw)NO are seen in cystic fibrosis, primary ciliary dyskinesia and in smoking subjects. More studies are needed to evaluate the clinical usefulness of the extended NO analysis, similar to what has been done in systemic sclerosis where a cut-off value has been identified predicting pulmonary function deterioration.
延长的 NO 分析是一种有前途的工具，可用于改变 NO 代谢的不同疾病。单次呼气并不能深入了解呼吸系统中的 NO 生成情况；相反，使用多次呼气流量可以提供肺泡水平（C(A)NO）、气道壁浓度（C(aw)NO）和 NO 的扩散速率（D(aw)NO）。在 COPD、系统性硬化症、肝肺综合征和严重哮喘中，C(A)NO 值增加。在哮喘中，C(aw)NO 和 D(aw)NO 增加，导致支气管 NO 通量（J'(aw)NO）增加。在囊性纤维化、原发性纤毛运动障碍和吸烟人群中，J'(aw)NO 水平较低。需要更多的研究来评估延长的 NO 分析的临床用途，类似于在系统性硬化症中所做的那样，已经确定了一个预测肺功能恶化的截断值。
