Scorsetti Marta, Alongi Filippo, Navarria Piera, Cortinovis Diego, Bidoli Paolo
Department of Radiotherapy and Radiosurgery, Humanitas Cancer Center, IRCCS Istituto Clinico Humanitas Rozzano, Italy.
Tumori. 2012 Mar-Apr;98(2):31e-34e. doi: 10.1700/1088.11944.
The best treatment approach for solitary brain metastasis is not well defined and there is no consensus on this issue. It is still being debated whether patients with isolated brain metastasis should undergo surgical resection or stereotactic radiosurgery, and which patients should receive adjuvant whole brain radiotherapy. The median survival in patients with single or multiple metastatic lesions who underwent only stereotactic radiosurgery improved from two-three months to nine months. To the best of our knowledge this is the first report on patients treated with linear accelerator-based stereotactic radiosurgery alone where an overall survival of more than 12 years was obtained, maintaining good quality of life in three cases of solitary brain metastasis from non-small cell lung cancer. In addition to the case reports, we present a brief literature review on this topic.
孤立性脑转移瘤的最佳治疗方法尚未明确界定，在这个问题上也没有达成共识。对于孤立性脑转移瘤患者是否应接受手术切除或立体定向放射外科治疗，以及哪些患者应接受辅助全脑放疗，仍存在争议。仅接受立体定向放射外科治疗的单发或多发转移瘤患者的中位生存期从两三个月提高到了九个月。据我们所知，这是首篇关于仅接受基于直线加速器的立体定向放射外科治疗的患者的报告，其中3例非小细胞肺癌孤立性脑转移患者获得了超过12年的总生存期，且生活质量良好。除了病例报告外，我们还对该主题进行了简要的文献综述。
