Department of Psychiatry, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Seoul 135-720, Korea.
Eur Arch Psychiatry Clin Neurosci. 2013 Apr;263(3):259-69. doi: 10.1007/s00406-012-0334-7. Epub 2012 Jun 8.
Having a relationship with one's parents is a fundamental social interaction and is a significant environmental factor in the long-term course of illness in schizophrenia. We explored subjective reports regarding the communicative relationship with parents and the implicit behavioral and neural responses of patients toward stimuli that referred to parents. Fourteen outpatients with schizophrenia and 15 healthy volunteers with living parents were scanned using a functional magnetic resonance imaging while performing an imaginary sentence completion test that involved contemplation of their mothers and fathers. In patients with schizophrenia, subjective reports of better communicative fluency with one's mother were associated with faster response time and lower incomplete rate, reflecting favorable responses toward mothers. Relative to control participants, patients with schizophrenia demonstrated greater neural activation in the superior temporal sulcus and the parahippocampal gyrus for parental stimuli. When patients with schizophrenia contemplated their mothers, activities in these regions were associated with a level of negative symptoms or affective ambivalence in patients. The results indicated that parental cues are processed in a more socially driven manner, and that perceived communicative relationships with one's parents can be used to estimate implicit responses, especially in relation to mothers in patients with schizophrenia. Furthermore, the findings of the current study suggest that affective ambivalence toward one's mother is one such implicit response and emphasize the importance of prudent family interventions in the psychiatric rehabilitation of patients with schizophrenia.
与父母的关系是一种基本的社会互动，是精神分裂症长期病程中的一个重要环境因素。我们探讨了患者对与父母沟通关系的主观报告，以及对涉及父母的刺激的隐含行为和神经反应。14 名精神分裂症门诊患者和 15 名有健在父母的健康志愿者在进行想象句子完成测试时接受了功能磁共振成像扫描，该测试涉及对母亲和父亲的思考。在精神分裂症患者中，与母亲沟通流畅的主观报告与更快的反应时间和更低的不完整率相关，反映了对母亲的有利反应。与对照组相比，精神分裂症患者在对父母的刺激时，上颞回和海马旁回的神经活动增加。当精神分裂症患者思考他们的母亲时，这些区域的活动与患者的阴性症状或情感矛盾水平有关。结果表明，父母线索以更具社会驱动的方式被处理，与父母的感知沟通关系可以用来估计隐含反应，尤其是在精神分裂症患者的母亲方面。此外，本研究的结果表明，对母亲的情感矛盾是一种隐含反应，并强调在精神分裂症患者的精神康复中谨慎进行家庭干预的重要性。
