Oesterwitz H
Urological Clinic, Friedrichshain Hospital, Berlin, G.D.R.
Z Versuchstierkd. 1990;33(5):211-5.
Heart transplantation in the rat is a frequently used model to study immunological problems of primary, vascularized allografts. A modified technique of heterotopic grafting is described in detail. The donor heart is transplanted heterotopically into the recipient with the brachiocephalic artery anastomosed to the renal artery with 10 single sutures, and the pulmonary artery to the renal vein with 2 continuous, semicircular sutures which were left untied. Both anastomoses were done end-to-end with 10-0 Ethilon. The experience with 187 rat heart transplants are reported. The time needed for one transplantation ranged from 25 to 35 min (mean 30 min). Complications like bleeding, thrombosis and primary no-function did occur in 12 out of 187 transplants (6.4%). In conclusion, this modified technique of heterotopic heart transplantation in the rat is less time consuming and highly successful.
大鼠心脏移植是研究原发性血管化同种异体移植物免疫问题时常用的模型。本文详细描述了一种改良的异位移植技术。将供体心脏异位移植到受体体内，用10根单缝线将头臂动脉与肾动脉吻合，用2根连续的半圆形缝线将肺动脉与肾静脉吻合，缝线暂不打结。两种吻合均采用10-0 Ethilon缝线进行端对端吻合。报告了187例大鼠心脏移植的经验。一次移植所需时间为25至35分钟（平均30分钟）。187例移植中有12例（6.4%）出现出血、血栓形成和原发性无功能等并发症。总之，这种改良的大鼠异位心脏移植技术耗时较少且成功率高。
