Lotosh N Iu, Lineva O A, Volkov I E, Mutalova Z M, Savel'ev S V, Selishcheva A A
Zh Nevrol Psikhiatr Im S S Korsakova. 2012;112(1):26-30.
To identify the association between distal peripheral neuropathy (DPN) and type 1 diabetes mellitus (T1D), 62 children and adolescents with different duration of T1D have been studied using electromyography (EMG). Subclinical symptoms of DPN occur with equal frequency in 74% of children with short duration of T1D (group 1) and in 72% of children with long duration of disease. In both groups, the highest frequency of disturbances of the neurophysiological parameters was found in the sural sensory nerve and the lowest frequency in the median motor nerve. Correlations between HbAlc levels and compound muscle action potential were revealed only in tibial and peroneal nerves and only in the early stages of T1D. However, this dependence disappears with increasing duration of the disease.
为确定远端周围神经病变（DPN）与1型糖尿病（T1D）之间的关联，我们使用肌电图（EMG）研究了62名不同病程的T1D儿童和青少年。DPN的亚临床症状在病程较短的T1D儿童（第1组）中有74%出现的频率相同，在病程较长的儿童中有72%出现的频率相同。在两组中，神经生理参数干扰频率最高的是腓肠感觉神经，最低的是正中运动神经。糖化血红蛋白（HbAlc）水平与复合肌肉动作电位之间的相关性仅在胫神经和腓神经中发现，且仅在T1D的早期阶段存在。然而，随着疾病病程的延长，这种相关性消失。
