Heil G, Weber A
Landesuntersuchungsamt für das Gesundheitswesen Nordbayern, Nürnberg.
Zentralbl Veterinarmed B. 1990 Nov;37(9):707-11.
Culture filtrates of 38 strains of Listeria (L.) monocytogenes and of 4 strains of L. ivanovii were all cytotoxic for the vero cell line. Culture filtrates from 35 strains of L. innocua, 12 strains of L. seeligeri, 5 strains of L. welshimeri and 4 strains of L. grayi showed no cytotoxicity for the continuous cell line vero. The use of continuous cell lines permits to distinguish between pathogenic and non-pathogenic Listeria strains and seems to be a suitable method to replace the mouse pathogenicity test or the fertilized hen's eggs test.
38株单核细胞增生李斯特菌（L. monocytogenes）和4株伊氏李斯特菌（L. ivanovii）的培养滤液对非洲绿猴肾细胞系（vero cell line）均具有细胞毒性。35株无害李斯特菌（L. innocua）、12株斯氏李斯特菌（L. seeligeri）、5株威氏李斯特菌（L. welshimeri）和4株格氏李斯特菌（L. grayi）的培养滤液对连续细胞系vero无细胞毒性。使用连续细胞系能够区分致病性和非致病性李斯特菌菌株，似乎是替代小鼠致病性试验或受精鸡蛋试验的合适方法。
