National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
J Mol Cell Biol. 2012 Aug;4(4):262-5. doi: 10.1093/jmcb/mjs031. Epub 2012 Jun 7.
The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional activity of these key pluripotency factors. Recent evidence highlights the important role of post-translational modifications, including ubiquitination, sumoylation, phosphorylation, methylation, and acetylation, in regulating the levels and activity of pluripotency factors to achieve a balance between pluripotency and differentiation.
多能性的维持依赖于一个复杂的转录网络，该网络由一组关键的转录因子组成。多能干细胞对这些关键多能性因子的细胞丰度和转录活性的调节非常敏感。最近的证据强调了翻译后修饰（包括泛素化、SUMO 化、磷酸化、甲基化和乙酰化）在调节多能性因子的水平和活性以在多能性和分化之间取得平衡方面的重要作用。
