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Human iPSC-derived self-assembled cardiac organoids for evaluating drug developmental cardiotoxicity.

作者信息

Xiao Yi, Xu Pengfei, Bi Jinmiao, Song Moshi

机构信息

State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.

出版信息

Life Med. 2025 Jun 7;4(4):lnaf018. doi: 10.1093/lifemedi/lnaf018. eCollection 2025 Aug.

DOI:10.1093/lifemedi/lnaf018
PMID:40641908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12238535/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed53/12238535/c1ede8bbbf9d/lnaf018_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed53/12238535/b2c2c159cfb9/lnaf018_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed53/12238535/c1ede8bbbf9d/lnaf018_fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed53/12238535/b2c2c159cfb9/lnaf018_fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed53/12238535/c1ede8bbbf9d/lnaf018_fig2.jpg

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本文引用的文献

1
Increased Ca Transient Underlies RyR2-Related Left Ventricular Noncompaction.钙瞬变增加是与 RyR2 相关的左心室致密化不全的基础。
Circ Res. 2023 Jul 7;133(2):177-192. doi: 10.1161/CIRCRESAHA.123.322504. Epub 2023 Jun 16.
2
PregTox: A Resource of Knowledge about Drug Fetal Toxicity.PregTox：药物胚胎毒性知识资源
Biomed Res Int. 2022 Apr 16;2022:4284146. doi: 10.1155/2022/4284146. eCollection 2022.
3
The cardiac sodium channel gene SCN5A and its gene product NaV1.5: Role in physiology and pathophysiology.心脏钠通道基因SCN5A及其基因产物NaV1.5：在生理和病理生理中的作用。
Gene. 2015 Dec 1;573(2):177-87. doi: 10.1016/j.gene.2015.08.062. Epub 2015 Sep 8.
4
Insights into cardiac conduction system formation provided by HCN4 expression.HCN4表达对心脏传导系统形成的见解。
Trends Cardiovasc Med. 2015 Jan;25(1):1-9. doi: 10.1016/j.tcm.2014.08.009. Epub 2014 Sep 6.
5
Post-translational modulation of pluripotency.多能性的翻译后调控。
J Mol Cell Biol. 2012 Aug;4(4):262-5. doi: 10.1093/jmcb/mjs031. Epub 2012 Jun 7.
6
Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy.人诱导多能干细胞衍生的肝细胞：疾病建模、药物开发和细胞治疗的新希望。
Protein Cell. 2012 Apr;3(4):246-50. doi: 10.1007/s13238-012-2918-4. Epub 2012 Mar 22.
7
Nkx2-5 represses Gata1 gene expression and modulates the cellular fate of cardiac progenitors during embryogenesis.Nkx2-5在胚胎发育过程中抑制Gata1基因表达并调节心脏祖细胞的细胞命运。
Circulation. 2011 Apr 19;123(15):1633-41. doi: 10.1161/CIRCULATIONAHA.110.008185. Epub 2011 Apr 4.
8
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells.胰岛1在不同的心血管谱系中表达，包括起搏细胞和冠状血管细胞。
Dev Biol. 2007 Apr 1;304(1):286-96. doi: 10.1016/j.ydbio.2006.12.048. Epub 2006 Dec 29.
9
Function and biological roles of the Dickkopf family of Wnt modulators.Dickkopf家族Wnt调节因子的功能及生物学作用。
Oncogene. 2006 Dec 4;25(57):7469-81. doi: 10.1038/sj.onc.1210054.
10
The voltage-gated potassium channels and their relatives.电压门控钾通道及其相关蛋白
Nature. 2002 Sep 5;419(6902):35-42. doi: 10.1038/nature00978.