Zeng Xue, Liu Wa-Li, Zhao Ting
Department of Dermatology, Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 May;32(5):624-7.
To evaluate the clinical effectiveness and safety of Chinese medical facial mask comprehensive therapy in treating acne vulgaris.
Totally 233 acne vulgaris patients (FAS set) in I -III degree were randomly assigned to the facial mask group (113 cases) and the Western medicine group (120 cases). They were respectively treated with external application of Chinese medical facial mask (twice a week) and 5% benzoyl peroxide gel (Benzine, once in the evening). The treatment lasted for four successive weeks. The integrals of lesions and the improvement of Chinese medicine syndrome integrals were observed 1 week, 2 weeks and 4 weeks after treatment respectively. The occurrence of adverse reactions was recorded. The subjects' evaluation on using the Chinese medical facial mask comprehensive therapy was also recorded.
Totally 228 of the 233 patients completed the therapeutic course (7 cases of overtime, 221 cases of PPS set, 105 cases in the facial mask group and 116 cases in the Western medicine group). After 4 weeks of treatment, the lesions and the total effective rate of CM symptoms were obviously higher in the facial mask group than in the control group (46.9% vs 30.0%, 70.8% vs 55.8%, P < 0.05). The statistical results of FAS set and PPS set showed no difference. After 4 weeks of treatment, the integrals of PPS lesions and the CM syndrome integrals in the facial mask group were lower than in the Western medicine group, showing statistical difference (P < or = 0.05). After 2 weeks and 4 weeks of treatment, the integrals of lesions and the CM syndrome integrals of FAS set and PPS set were all higher in the facial mask group than in the control group (P < 0.05). The occurrence of adverse reactions was 1.8% (2/113) in the facial mask group and 2.5% (3/120) in the control group without statistical difference (P > 0.05).
Chinese medical facial mask comprehensive therapy is safe and effective in treating acne vulgaris of I - III degree. The occurrence of adverse reactions is very low. It is easy to operate and spread.
评价中药面膜综合疗法治疗寻常痤疮的临床疗效及安全性。
将233例Ⅰ-Ⅲ度寻常痤疮患者（FAS集）随机分为面膜组（113例）和西药组（120例）。分别给予中药面膜外用（每周2次）和5%过氧化苯甲酰凝胶（班赛，每晚1次）治疗。连续治疗4周。分别于治疗后1周、2周和4周观察皮损积分及中医证候积分改善情况。记录不良反应发生情况。记录受试者对使用中药面膜综合疗法的评价。
233例患者中228例完成疗程（7例超疗程，PPS集221例，面膜组105例，西药组116例）。治疗4周后，面膜组皮损及中医症状总有效率明显高于对照组（46.9% 对30.0%，70.8% 对55.8%，P<0.05）。FAS集和PPS集统计结果无差异。治疗4周后，面膜组PPS皮损积分及中医证候积分低于西药组，差异有统计学意义（P≤0.05）。治疗2周和4周后，面膜组FAS集和PPS集的皮损积分及中医证候积分均高于对照组（P<0.05）。面膜组不良反应发生率为1.8%（2/113），对照组为2.5%（3/120），差异无统计学意义（P>0.05）。
中药面膜综合疗法治疗Ⅰ-Ⅲ度寻常痤疮安全有效。不良反应发生率极低。操作简便，易于推广。
