Zhang Juan, Liu Lu-Ming, Chen Lian-Yu
The Graduate School, Shanghai University of Traditional Chinese Medicine, Shanghai 201203.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 May;32(5):657-60.
To compare different Chinese medicine (CM) therapeutic methods on the pancreatic orthotopic transplantation tumors in nude mice, and to explore their features.
The pancreatic orthotopic transplantation tumor model was established. Sixty nude mice were randomly divided into four group, i. e., the blood circulation activating and stasis resolving group, the heat clearing and dampness removing group, the Pi-strengthening and qi-regulating group, the phlegm reducing and mass resolving group, the normal control 1 group, and the normal control 2 group, 10 in each group. 0.2 mL corresponding CM decoction or normal saline was respectively administered to each group by gastrogavage, once daily, for totally 28 days. The body weight, the tumor weight, and the tumor inhibition ratio were observed.
The tumor inhibition ratio was 42.69% in the heat clearing and dampness removing group, 31.24% in the blood circulation activating and stasis resolving group, 2.11% in the Pi-strengthening and qi-regulating group, and -12.95% in the phlegm reducing and mass resolving group. There was statistical difference in the tumor weight between the heat clearing and dampness removing group and the normal control 1 group (g, 0.51 +/- 0.28 vs 0.90 +/- 0.25, P < 0.05). There was no statistical difference in the body weight change between the two groups (P > 0.05).
The CM pathogenesis of pancreatic carcinoma may possibly due to the accumulation of dampness and heat, or the accumulation of dampness, heat, and toxicity. Clearing heat and removing dampness may be the basic principle for its treatment.
比较不同中医治疗方法对裸鼠胰腺原位移植瘤的作用，并探讨其特点。
建立胰腺原位移植瘤模型。将60只裸鼠随机分为四组，即活血化瘀组、清热利湿组、健脾理气组、化痰软坚组、正常对照1组和正常对照2组，每组10只。分别给每组灌胃0.2 mL相应的中药汤剂或生理盐水，每日1次，共28天。观察体重、瘤重及抑瘤率。
清热利湿组抑瘤率为42.69%，活血化瘀组为31.24%，健脾理气组为2.11%，化痰软坚组为-12.95%。清热利湿组与正常对照1组瘤重比较有统计学差异（g，0.51±0.28 vs 0.90±0.25，P<0.05）。两组体重变化比较无统计学差异（P>0.05）。
胰腺癌的中医病机可能为湿热蕴结或湿热毒蕴结。清热利湿可能是其治疗的基本原则。
