[低剂量率电离辐射对大鼠小肠肠上皮细胞线粒体电子传递链状态的影响]

[The effect of ionizing radiation with low dose rate on the state of electron transfer chain of enterocyte mitochondria of rat small intestine].

作者信息

Grubskaia L V, Voĭtsitskiĭ V M, Khizhniak S V

出版信息

Ukr Biokhim Zh (1999). 2012 Jan-Feb;84(1):45-52.

Abstract

The influence of ionizing radiation with low absorbed dose rate (55 mGy x min(-1)) in 1, 12 and 24 hours after irradiation in doses of 0.1; 0.5 and 1.0 Gy on functional state of the electron transfer chain of the rat small intestine mitochondria was investigated by assessment of the oxygen consumption rate. The uncoupling of oxidation and phosphorylation, a decrease of phosphorylation rate and inhibition of ATP hydrolysis reactions were established in mitochondria in dependence on the irradiation dose and time interval after irradiation. The functional peculiarities of the oxidation-phosphorylation coupling sites of the mitochondrial electron transfer chain were detected.

摘要

研究了低吸收剂量率（55 mGy·min⁻¹）的电离辐射在照射后1、12和24小时，以0.1、0.5和1.0 Gy的剂量对大鼠小肠线粒体电子传递链功能状态的影响，通过评估氧气消耗率进行研究。根据照射剂量和照射后的时间间隔，在线粒体中发现了氧化与磷酸化的解偶联、磷酸化率的降低以及ATP水解反应的抑制。检测到了线粒体电子传递链氧化磷酸化偶联位点的功能特性。

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