Popov I, Ganchev S, Bakŭrdzhiev G
Akush Ginekol (Sofiia). 1990;29(4):20-3.
The authors investigate primiparous women at various ages, searching for eventual changes in uterine blood vessels and in the placenta, which eventually could have unfavourable effect on the fetus. The study established progressive thickening due to fibrosis of the muscular layer of the myometrial arteries (in reduction of smooth muscular elements) as well as delay of maturation and differentiation of placental villi with advancement of age of the pregnant woman. These phenomena independently could be the cause for more frequent unfavourable outcome of pregnancy in elderly pregnant women.
作者对不同年龄段的初产妇进行了研究，探寻子宫血管和胎盘最终可能发生的变化，这些变化最终可能会对胎儿产生不利影响。该研究证实，随着孕妇年龄的增长，子宫肌层动脉肌层因纤维化而逐渐增厚（平滑肌成分减少），同时胎盘绒毛的成熟和分化延迟。这些现象各自都可能是老年孕妇妊娠不良结局更常见的原因。
