Division of Vector-Borne Diseases (DVBD), Centers for Diseases Control and Prevention (CDC), 3150 Rampart Road, Fort Collins, CO 80521, USA.
J Med Entomol. 2012 May;49(3):678-86. doi: 10.1603/me11193.
Vector competence studies for West Nile virus (WNV) were conducted for two Culex (Culex) restuans Theobald populations Edison Park (EP) and Illinois Medical District (IMD), in Chicago, IL. The aim was to determine if there were differences between mosquito populations that contributed to the observed differences in the prevalence of WNV. Percentages of orally infected, disseminated, and transmitting mosquitoes were estimated using a generalized linear mixed effects model including a random effect for family to account for anticipated within-family correlation. Analysis indicated that percentages of infected, disseminated, and transmitting mosquitoes were not significantly different between EP and IMD. The within-family correlation was 0.46 (95% CI 0.28, 0.67), indicating reasonably strong tendency for WNV titers of bodies, saliva, and legs within families to be similar. Overall, our results show that vector competence of Cx. restuans for WNV is not a contributing factor to the observed differences in WNV human cases between the EP and IMD areas of Chicago.
西尼罗河病毒（WNV）的媒介效能研究针对伊利诺伊州芝加哥市的爱迪生公园（EP）和伊利诺伊州医疗区（IMD）的两种库蚊（Culex）restuans 种群进行。目的是确定蚊子种群之间是否存在差异，这些差异导致了WNV 流行率的观察差异。使用广义线性混合效应模型估计了经口感染、传播和传播蚊子的百分比，该模型包括一个家庭随机效应，以解释预期的家庭内相关性。分析表明，EP 和 IMD 之间感染、传播和传播蚊子的百分比没有显著差异。家庭内相关性为 0.46（95%CI 0.28, 0.67），表明家庭内蚊子身体、唾液和腿部的 WNV 滴度具有相当强的相似趋势。总体而言，我们的结果表明，WNV 对 Cx. restuans 的媒介效能不是导致 EP 和 IMD 地区 WNV 人类病例观察差异的因素。
