泮库溴铵在新生儿、婴儿及儿童中的剂量反应特性。

Dose-response characteristics of pancuronium in neonates, infants and children.

作者信息

Meretoja O A, Luosto T

机构信息

Department of Anaesthesiology, Children's Hospital, University of Helsinki, Finland.

出版信息

Anaesth Intensive Care. 1990 Nov;18(4):455-9. doi: 10.1177/0310057X9001800406.

DOI:10.1177/0310057X9001800406

PMID:2268009

Abstract

This paper presents pharmacodynamic data for pancuronium in neonates, infants, children and adolescents during N2O-O2-fentanyl anaesthesia. Neuromuscular block (NMB) was evaluated by the adductor pollicis electromyogram. Dose-response curves of pancuronium were parallel in all age-groups. ED95 was greatest in children and least in infants (93 vs. 66 micrograms/kg, P less than 0.05). The rate of spontaneous recovery following 95% NMB was comparable in all age-groups, as was the maintenance requirement of pancuronium when related to ED-values. The hourly requirement to maintain NMB greater than 85% was 60-68% of the individual ED95 dose. When administered on this basis, pancuronium is an equally long-acting neuromuscular blocking agent in patients of all ages.

摘要

本文介绍了泮库溴铵在氧化亚氮-氧气-芬太尼麻醉期间用于新生儿、婴儿、儿童和青少年的药效学数据。通过拇内收肌肌电图评估神经肌肉阻滞（NMB）。泮库溴铵的剂量-反应曲线在所有年龄组中都是平行的。儿童的ED95最大，婴儿最小（93微克/千克对66微克/千克，P<0.05）。所有年龄组95%神经肌肉阻滞自发恢复率相当，泮库溴铵维持量与ED值相关时也是如此。维持神经肌肉阻滞大于85%的每小时需求量为个体ED95剂量的60-68%。在此基础上给药时，泮库溴铵在所有年龄患者中都是作用时间同样长的神经肌肉阻滞剂。