Department of Psychology, Brain and Mind Institute, University of Western Ontario, Canada.
J Neurosurg. 2012 Aug;117(2):218-24. doi: 10.3171/2012.4.JNS112158. Epub 2012 Jun 8.
Compression induced by a pituitary tumor on the optic chiasm can generate visual field deficits, yet it is unknown how this compression affects the retinotopic organization of the visual cortex. It is also not known how the effect of the tumor on the retinotopic organization of the visual cortex changes after decompression. The authors used functional MRI (fMRI) to map the retinotopic organization of the visual cortex in a 68-year-old right-handed woman before and 3 months after surgery for a recurrent pituitary macroadenoma. The authors demonstrated that longitudinal changes in visual field perimetry, as assessed by the automated Humphrey visual field test, correlated with longitudinal changes in fMRI activation in a retinotopic manner. In other words, after decompression of the optic chiasm, fMRI charted the recruitment of the visual cortex in a way that matched gains in visual field perimetry. On the basis of this case, the authors propose that fMRI can chart neural plasticity of the visual cortex on an individual basis and that it can also serve as a complementary tool in decision making with respect to management of patients with chiasmal compression.
垂体瘤对视交叉的压迫可导致视野缺损，但尚不清楚这种压迫如何影响视皮层的视网膜组织。也不知道肿瘤对视皮层视网膜组织的影响在减压后如何变化。作者使用功能磁共振成像（fMRI）在一位 68 岁的右利手女性中绘制了视皮层的视网膜组织图，该女性在复发的垂体大腺瘤手术后 3 个月进行了手术。作者证明，通过自动 Humphrey 视野测试评估的视野测量的纵向变化与 fMRI 激活的纵向变化以视网膜组织的方式相关。换句话说，在视交叉减压后，fMRI 以与视野测量增益相匹配的方式绘制了视皮层的募集情况。基于该病例，作者提出 fMRI 可以在个体基础上绘制视皮层的神经可塑性，并且可以作为对视交叉压迫患者管理的决策制定的补充工具。
