HIV感染患者的肺功能变化：一项4.5年的随访研究。
Changes in lung function of HIV-infected patients: a 4.5-year follow-up study.
作者信息
Kristoffersen Ulrik Sloth, Lebech Anne-Mette, Mortensen Jann, Gerstoft Jan, Gutte Henrik, Kjaer Andreas
机构信息
Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Copenhagen, Denmark.
出版信息
Clin Physiol Funct Imaging. 2012 Jul;32(4):288-95. doi: 10.1111/j.1475-097X.2012.01124.x. Epub 2012 Mar 11.
OBJECTIVE
To investigate the development of lung function in HIV-infected patients.
METHODS
In a prospective cohort study, 88 HIV-infected patients had a lung function test performed and 63 patients (72%) had their LFT repeated with a median follow-up period of 4.4 years. Forty-eight per cent were smokers, and at the re-examination, 97% were on combination antiretroviral therapy.
RESULTS
Carbon monoxide diffusion capacity was reduced and decreased over time in both smokers and non-smokers. Alveolar volume decreased and forced vital capacity increased similarly in both smokers and non-smokers. No changes were observed in forced expiratory volume or peak flow, but smokers had reduced values compared with those of the non-smokers at both examinations. FEV1/FVC was reduced especially in smokers and declined in both smokers and non-smokers.
CONCLUSIONS
Carbon monoxide diffusion capacity is reduced in HIV-infected patients and seems to decline over time. Additionally, signs of obstructive lung disease are present in HIV-infected patients and seem to increase over time, although only modestly.
目的
研究人类免疫缺陷病毒（HIV）感染患者的肺功能发展情况。
方法
在一项前瞻性队列研究中，88例HIV感染患者接受了肺功能测试，其中63例患者（72%）在中位随访期4.4年时重复进行了肺功能测试。48%的患者为吸烟者，在复查时，97%的患者正在接受联合抗逆转录病毒治疗。
结果
吸烟者和非吸烟者的一氧化碳弥散量均降低且随时间下降。吸烟者和非吸烟者的肺泡容积均减小，用力肺活量均增加。用力呼气量或峰值流速未观察到变化，但在两次检查中，吸烟者的值均低于非吸烟者。第一秒用力呼气容积/用力肺活量尤其在吸烟者中降低，且吸烟者和非吸烟者均下降。
结论
HIV感染患者的一氧化碳弥散量降低，且似乎随时间下降。此外，HIV感染患者存在阻塞性肺疾病的迹象，且似乎随时间增加，尽管增幅较小。
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