Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55904, USA.
Lung Cancer. 2012 Sep;77(3):611-6. doi: 10.1016/j.lungcan.2012.05.096. Epub 2012 Jun 6.
Lung cancer is associated with a multitude of challenges, and lung cancer survivors report significantly lower quality of life (QOL) than other cancer survivors.
This study aimed to examine the relationship between physical activity level and QOL in a large sample of long term lung cancer survivors (N=1937). Average age at diagnosis was 65 years, 92% were Caucasian, and 51% male. Surveys were completed at lung cancer diagnosis and then average 4.2 years post-diagnosis.
Most survivors reported having a sedentary lifestyle at both timepoints. However, 256 survivors reported a change in physical activity level from diagnosis to follow-up. Decreased physical activity (n=140) was associated with decreased overall, mental, physical, emotional, social, and spiritual QOL (all ps<.001) and decreased symptom control as seen in reported pain, dry coughing, coughing with phlegm, shortness of breath, and level of fatigue (all ps<.05). In contrast, increased physical activity (n=116) was associated with improved QOL (all ps<.05), and improved symptom control as seen in frequency and severity of pain (p<.01). For all participants, those engaging in regular physical activity (30 min or more per day, at least five days per week) reported significantly higher QOL scores (all ps<.001), and better symptom control than more sedentary survivors.
Results indicate a significant association between change in physical activity and QOL and symptom control for long term lung cancer survivors, and research exploring interventions designed to improve activity level for lung cancer survivors is further warranted.
肺癌患者面临着诸多挑战，与其他癌症幸存者相比，肺癌幸存者的生活质量显著降低。
本研究旨在通过对大量长期肺癌幸存者（N=1937）的样本，研究身体活动水平与生活质量之间的关系。诊断时的平均年龄为 65 岁，92%为白种人，51%为男性。在肺癌诊断时和诊断后平均 4.2 年完成了调查。
大多数幸存者在两个时间点都报告了久坐的生活方式。然而，有 256 名幸存者报告了身体活动水平从诊断到随访的变化。与身体活动减少（n=140）相关的是整体、心理、身体、情感、社会和精神生活质量下降（均 p<.001），以及报告的疼痛、干咳、咳痰、呼吸急促和疲劳程度的症状控制下降（均 p<.05）。相比之下，身体活动增加（n=116）与生活质量的改善相关（均 p<.05），以及疼痛频率和严重程度的症状控制改善（p<.01）。对于所有参与者，那些经常进行身体活动（每天至少 30 分钟，每周至少五天）的人报告了更高的生活质量评分（均 p<.001），且症状控制也优于更久坐的幸存者。
结果表明，长期肺癌幸存者的身体活动变化与生活质量和症状控制之间存在显著关联，进一步需要研究旨在提高肺癌幸存者活动水平的干预措施。
